** Update **
Please read this blog post for additional information.

I noticed in some environments that after installing XA650W2K8R2X64025 and HDXFlash200WX64001 for XenApp 6.5 (wich fixes a lot of flash redirection issues in XA65) the users are getting an popup in Internet Explorer about the VDAredirector.exe opening outside IE protected mode :

(Screenshot is from a user with the Dutch language pack enabled)

English message :

This program will open outside of Protected mode. Internet Explorer’s Protected mode helps protect your computer. If you do not trust this website, do not open this program.

Name: Citrix FTA, URL VDA Redirector
Publisher: Citrix Systems, INC

Resolution :

After selecting “Do not show me the warning for this program again” and clicking on “Allow” i searched the registry and found the following key :

[HKCU\Software\Microsoft\Internet Explorer\Low Rights\ElevationPolicy\{BFFC40A2-FFE2-4E6F-B179-3641561D4FCD}]
“AppName”=”VDARedirector.exe”
“AppPath”=”C:\\Program Files (x86)\\Citrix\\system32”
“Policy”=dword:00000003

Import this registry key into RES Workspace Manager (loginscript or other environment manager software you are using) apply it to your users and they will not be bothered with this warning message!